The Dow concluded its best month in more than three decades Monday, with gains propelled by expectations for a 2021 recovery based on coronavirus vaccine progress.
The blue-chip index suffered a 0.9 percent drop in the session to finish at 29,638.64, but that's nearly a 12 percent gain for all of November, making it the best month since January 1987.
The broad-based S&P 500 dropped 0.5 percent to 3,621.63, while the tech-rich Nasdaq Composite Index slipped 0.1 percent to 12,198.74.
The November gains followed a bruising October amid worries over rising coronavirus cases and fears of a contested US presidential election.
But stocks have gained ground since the November 3 US presidential election as investors now expect an uneventful transfer of power at the White House, even though President Donald Trump has not conceded the race to former vice president Joe Biden.
Trump has filed dozens of lawsuits but Biden's victory has been confirmed after key states certified the results.
Besides easing fears over political uncertainty, markets haverallied in the wake of a series of upbeat announcements on coronavirus vaccines, including one on Monday from Moderna.
Those advances have diminished the drag on sentiment even as US coronavirus cases push to new records.
Moderna surged 20.2 percent after announcing it would file requests for emergency authorization of its Covid-19 vaccine in the United States and Europe, after full results confirmed a high efficacy estimated at 94.1 percent.
Nikola plunged 26.9 percent after it reached a revised and sharply pared-down deal with General Motors, which will no longer take a stake in the electric-truck startup. GM fell 2.7 percent.
IHS Markit jumped 7.4 percent after reaching a deal to be acquired by S&P Global for $44 billion, creating a massive enterprise to produce data and analytics used by Wall Street.
The firms said joining forces will bolster offerings to investor clients and provide complementary information streams in growth areas, such as in the shifts towards renewable energy. S&P Global gained 3.0 percent.