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Tokyo stocks closed lower on Wednesday, with investor sentiment dampened by a strong yen and declines on Wall Street.

The key Nikkei 225 index fell 1.15 percent, or 260.27 points, to 22,397.11, extending its losing streak for a fourth trading day.

The broader Topix index dropped 1.28 percent, or 20.08 points, to 1,549.04.