TOKYO, Oct. 2 (Xinhua) -- Tokyo stocks closed lower on Wednesday following weak key U.S. manufacturing data.

File photo: AFP

The 225-issue Nikkei Stock Average decreased 106.63 points, or 0.49 percent, from Tuesday at 21,778.61.

The broader Topix index of all First Section issues on the Tokyo Stock Exchange ended 6.71 points, or 0.42 percent, lower at 1,596.29.

Machinery, transportation equipment and mining issues comprised those that increased the most.