TOKYO, Nov. 18 (Xinhua) -- Tokyo stocks closed lower Wednesday, as investors were cautious about a resurgence of COVID-19 infections in Japan and abroad.

The 225-issue Nikkei Stock Average lost 286.48 points or 1.10 percent from Tuesday to close at 25,728.14.

The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, ended 14.01 points or 0.81 percent lower at 1,720.65.

Nonferrous metal, air transportation and marine transportation issues comprised those that decreased the most by the close of play.