Tokyo stocks opened lower on Thursday in cautious trade after a mixed close on Wall Street, as investors digested the latest economic data and news on virus vaccines.

The benchmark Nikkei 225 index was down 0.28 percent or 80.11 points at 28,794.78 in early trade while the broader Topix index slipped 0.21 percent or 4.18 points to 1,944.96.