CHINA Chinese study unlocks clues to fight African swine fever

CHINA

Chinese study unlocks clues to fight African swine fever

Xinhua

13:52, October 18, 2019

BEIJING, Oct. 18 (Xinhua) -- Chinese scientists have unraveled the three dimensional structure of the African swine fever virus, laying a solid foundation for developing effective and safe vaccines against the disease.

42ef2ad5444a484f9b684b07fcb2ebb7.jpg

File photo: CGTN

The research, jointly conducted by scientists at the Institute of Biophysics of the Chinese Academy of Sciences and the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, was published in the latest issue of the academic journal Science.

Scientists successfully isolated the epidemic strain of the African swine fever virus, which is spreading in China. It took the research team four months to collect over 100 TB of high-quality data.

The research showed the virus has a unique structure of five layers: the outer membrane, capsid, double-layer inner membrane, core shell and genome.

It contains more than 30,000 protein sub-units, forming a spherical particle with a diameter of about 260 nanometers.

The study identified structural proteins of the virus, revealing potential protective antigens and key information on the epitope, the part of an antigen molecule to which an antibody attaches itself.

The research also showed the complex arrangement and interaction mode of the structural proteins, and proposed the possible assembly mechanism of the virus, providing an important clue as to how it invades host cells and evades and antagonizes the host antiviral immunity.

Related Stories

Terms of Service & Privacy Policy

We have updated our privacy policy to comply with the latest laws and regulations. The updated policy explains the mechanism of how we collect and treat your personal data. You can learn more about the rights you have by reading our terms of service. Please read them carefully. By clicking AGREE, you indicate that you have read and agreed to our privacy policies

Agree and continue