Carrying multiple people who have tested positive for COVID-19, the Grand Princess maintains a holding pattern about 30 miles off the coast of San Francisco, March 8, 2020. The cruise ship is scheduled to dock at the Port of Oakland on Monday. (Photo: AP)

Federal and state officials in California prepared to receive thousands of people Monday from a cruise ship that has been idling off the coast of San Francisco with at least 21 people aboard infected with the coronavirus.

Personnel covered head to toe in protective gear woke passengers on the Grand Princess to check whether they have symptoms of COVID-19.

Michele Smith, of Paradise, California, said a doctor knocked on her and her husband’s cabin before dawn and asked if they had a fever or a cough. The couple who went on the cruise to celebrate their wedding anniversary are healthy and, like the rest of the 2,400 passengers aboard, have been isolating in their cabins since Thursday.

On land, fences were installed at an 11-acre site at the Port of Oakland as authorities readied flights and buses to whisk the passengers aboard the ship to military bases or their home countries for a 14-day quarantine. The more than 3,500 passengers and crew on the ship hail from 54 countries.

“We’re making every effort to get them off the ship as safely and quickly as possible,” said Dr. John Redd of the U.S. Department of Health and Human Services, who urged passengers to remain in their rooms.

The number of infections in the United States climbed above 500, with at least 21 deaths, as testing increased. The virus has infected more than 110,000 worldwide, with Italy becoming the latest country to lock down a region in an attempt to prevent its spread. On Wall Street, a combination of coronavirus fears and plunging oil prices sent stocks plummeting Monday.

In California, Gov. Gavin Newsom and the mayor of Oakland sought to reassure the public that none of the Grand Princess passengers would be exposed to the U.S. public before completing the quarantine.

The Port of Oakland was chosen for docking because of its proximity to an airport and a military base, Newsom said. U.S. passengers will be transported to military bases in California, Texas and Georgia, where they’ll be tested for the COVID-19 virus and quarantined.

About 1,100 crew members, 19 of whom have tested positive for the new virus, will be quarantined and treated aboard the ship, which will dock elsewhere, Newsom said.

“That ship will turn around — and they are currently assessing appropriate places to bring that quarantined ship — but it will not be here in the San Francisco Bay,” he said.

Dr. Anthony Fauci, the National Institutes of Health’s infectious diseases chief, said Sunday that widespread closure of a city or region is “possible.” U.S. Surgeon General Jerome Adams said communities will need to start thinking about canceling large gatherings, closing schools and letting more employees work from home, as many companies have done in the Seattle area amid an outbreak at a care home that has killed 17.

On the Grand Princess, the Smiths said they hope their time spent in quarantine on the ship will count toward the 14 days they are expected to isolate themselves. But they said officials have not yet provided an answer.

“We would love to get credit for the three or four days we’ve spent in our cabin,” Steven Smith said.

The Department of State was working with the home countries of several hundred passengers to arrange their repatriation, including nearly 240 from Canada.

The ship has been held off the coast amid evidence it was the breeding ground for a cluster of at least 20 cases from a previous voyage. Six Canadians who were on the Grand Princess from Feb. 11 to 21 were confirmed Monday to have the virus.

Meanwhile, another cruise ship, the Regal Princess, pulled into a Florida port late Sunday night after being held off the state’s coast for hours while awaiting coronavirus test results for two crew members, who did not have symptoms consistent with COVID-19.

Another Princess ship, the Diamond Princess, was quarantined for two weeks in Yokohama, Japan, last month because of the virus. Ultimately, about 700 of the 3,700 people aboard became infected in what experts pronounced a public health failure, with the vessel essentially becoming a floating germ factory.

On Sunday, the U.S. State Department urged U.S. citizens against travel on cruise ships as officials said there was an “increased risk of infection of COVID-19 in a cruise ship environment.”

Some public venues in the U.S. have been taking safety measures in an effort to limit the virus’ spread. Several universities have begun online-only courses and the largest school district in Northern California, with 64,000 students, canceled classes for a week when it was discovered a family in the district was exposed to COVID-19.